Synaptophysin serves as an essential marker for neuroendocrine differentiation and is instrumental in diagnosing various neuroendocrine tumors and neural disorders. Given its broad expression in neuroendocrine cells across various tissues, it plays a vital role in identifying neuroendocrine tumors of the adrenal medulla, thyroid, lung, and pancreas, as well as neural tissues like the brain and spinal cord. 

Using Synaptophysin IHC effectively helps identify neuroendocrine differentiation in a wide range of tissue types and conditions, contributing to accurate diagnoses and treatment planning.